Previous studies have found an inverse relationship between B vitamins and homocysteine levels. Likewise, higher homocysteine levels have been linked to atherosclerosis and higher risks of fatal coronary heart disease (CHD) and strokes. CHD studies have found a reduction in the average level of homocysteine since folic acid fortification was instituted in the U.S. A new study ties low serum folate levels with increased risk of depression symptoms as well. The cross-sectional population-based study is one of the first conducted among U.S. adults since the mandatory fortification of folic acid. The study also looked at vitamin B12 and total homocysteine (tHcy) levels as well. Folate is a water-soluble B vitamin naturally occurring in food. Folic acid is the synthetic form added to foods for fortification or in supplements. Diets rich in whole foods typically are rich in folate since leafy green vegetables, citrus fruits and dried beans and peas all provide natural sources. Since the 1996 FDA requirement of folic acid fortification, enriched breads, cereals, flours, pastas, rice, and other grain products, provide other popular sources to the American diet. Since depression is a common medical condition, surrounded by myths and misconceptions about its causes, symptoms and seriousness, learning more about its relationship with folate levels could be beneficial for those that are trying to cope. Researchers for the study, published online last month in Psychosomatic Medicine, used cross-sectional information from NHANES data collected from 2005-2006. Data from more than 2,500 adults between 20-85 years of age were included. In addition to folate, vitamin B12, and total homocysteine levels, researchers also looked at data related to demographics, diet, physical activity, smoking habits, blood pressure, and depressive symptoms. The study indentified a significant association between folate levels and elevated depressive symptoms as well as elevated homocysteine levels especially in people over the age of 50. So what do these results mean for those dealing with depression issues? Blood tests to evaluate folate and homocysteine levels may be of benefit. Identified out of balance levels would suggest dietary strategies could be beneficial to mood improvement. It is also important to be aware of medical conditions or medications that could be interfering with folate metabolism, which could result in low serum levels despite adequate intake amounts. Medical conditions which increase need for folate or increased losses of folate include:
A new study found a correlation between depression symptoms and low serum folate levels. There are a variety of medical conditions and medications that can negatively influence folate absorption. The RDA for folate for adults is 400 ug/day for both males and females with an increase for woman who are of child bearing age to a minimum of 600 ug/day. To be sure you have a diet rich in folate or folic acid, eat a balanced diet. Include natural sources of folate such as beans, lentils, orange juice, and leafy greens as often as possible. Fortified sources of folic acid also supply a well balanced diet through enriched breads, cereals, flour, corn meals, pastas, rice, and other grain products. Be aware of the folic acid content of vitamins and supplements and your overall folic acid intake from those and other fortified and enriched foods and speak with your medical professional regarding any symptoms you may be experiencing especially if you have a medical condition or take a medication that could reduce folate use by the body. Serum blood evaluation may be beneficial in those situations. Have you dealt with depression issues at any time in your life? Do you have any medical conditions or take medications that could be influencing body folate use? What are some of your favorite folate rich foods or meals? |
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